PhD student researcher
Universitätsmedizin Göttingen UMG · Göttingen, Germany
You apply on the site where the job is posted. I never handle applications.
Ihre Aufgaben
- establish, maintain and validate compartment-targeted ROS-generating cell models
- perform quantitative live-cell imaging using genetically encoded redox biosensors
- analyse compartment-specific ROS propagation and redox signalling
- contribute to redox proteomics, translation assays and mitochondrial functional studies
- work with iPSC-derived cardiomyocytes and neuronal models
- integrate imaging, proteomic, transcriptomic and functional datasets
- coordinate experimental workflows with collaboration partners
- contribute to publications, presentations and supervision of junior researchers
Ihre Qualifikationen
Completed Master of Sciences or equivalent in a Life Sciences subject (molecular medicine, biology, chemistry, physics, …)
- experience in live-cell fluorescence imaging and quantitative image analysis
- experience with genetically encoded biosensors, redox biology, mitochondrial biology or protein translation
- practical experience with mammalian cell culture; experience with iPSC-derived cardiomyocytes or neurons is an advantage
- experience with molecular cloning, viral transduction, CRISPR-based approaches or engineered cell model
- interest in integrating imaging data with proteomics, transcriptomics or functional assays
- strong organisational skills and the ability to work independently in an interdisciplinary research environment
- excellent communication skills and fluency in English
Wir bieten
- Structured PhD training within GAUSS/GGNB with additional and optional training in the the RTG2824 “Heart and brain diseases: integrative research across organs”
- a scientifically ambitious and well-supported project within a highly collaborative CRC environment
- access to established DAO- and SuperNova-based ROS tools, redox biosensors and iPSC-derived cell models
- close collaboration with experts in redox proteomics, mitochondrial translation, iPSC engineering, mitochondrial imaging, metabolic flux analysis and mitochondrial quality control
- an excellent scientific environment at the University Medical Center Göttingen
- opportunities for publications, conference participation, methodological training and career development
Einleitungstext
The Institute of Cardiovascular Physiology at the University Medical Center Göttingen invites applications for a PhD student reseacher position to work within a project on compartment-specific mitochondrial redox signalling and protein translation.
The project investigates how localized production of H₂O₂ and O₂•⁻ within mitochondrial subcompartments and the cytosol regulates thiol-dependent redox networks, mitochondrial and cytoplasmic protein translation, and cellular adaptation. The work will use genetically encoded ROS-generating systems, including DAO- and SuperNova-based tools, in HEK293 cells, human iPSC-derived cardiomyocytes and neurons. The project combines live-cell redox imaging, engineered cell models, redox proteomics, translation assays, mitochondrial functional analyses and multi-omics integration.