Postdoc in quantitative characterisation of multivalent binding

KTH Royal Institute of Technology · Stockholm, Sweden

No Swedish requiredPosted today

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Job description

We are looking for a postdoc to develop new methods for measuring multivalent binding — the mechanism by which antibodies and many modern therapeutics engage several targets at once. Standard binding assays capture this poorly, which limits how well the behaviour of such molecules can be predicted.

The project combines DNA nanotechnology with amplification- and sequencing-based readouts. You will use programmable DNA nanostructures to present targets at controlled nanometre spacings, and develop assays that quantify how binders engage them. The work is method development with applications in mind, carried out together with the experimental and computational members of the group at the Department of Gene Technology, KTH/SciLifeLab

Qualifications

Requirements

A doctoral degree or an equivalent foreign degree. This eligibility requirement must be met no later than the time the employment decision is made.
Documented experience of quantitative molecular biology methods, such as qPCR, digital PCR or DNA sequencing.
Very good command of English, spoken and written, as this is the working language of the research group.

As a person you are independent and used to driving a research project forward on your own initiative. The work takes place in an interdisciplinary environment, which calls for good collaborative skills and the ability to communicate results clearly. We prefer that you are aware of diversity and equal opportunity issues, with specific focus on gender equality.

Preferred qualifications

A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline.
Experience of DNA nanotechnology or other forms of programmable molecular self-assembly.
Experience of characterising molecular binding interactions, for example using surface-based or biophysical methods.
Ability to combine experimental work with quantitative data analysis or modelling.·
Experience of supervising students or teaching at university level.

Great emphasis will be placed on personal skills.

Join us at KTH

KTH shapes the future through education, research and innovation. As a leading international technical university, we play an active role in advancing the transition towards a sustainable society. At KTH, you have the opportunity to grow and develop in a creative and dynamic environment, with good working conditions and attractive benefits. Equality, diversity and equal opportunities are essential to quality and form an integral part of KTH’s core values as a university and public authority.

Learn more about our benefits and what it's like to work and grow at KTH.

Trade union representatives

Contact information totrade union representatives.

To apply for the position

Log into KTH's recruitment system to apply for this position. You are responsible for ensuring that your application is complete according to the instructions in the ad.

The application must include:

CV including relevant professional experience and knowledge.
Copy of diplomas and grades from your previous university studies. Translations into English or Swedish if the original documents have not been issued in any of these languages.
Brief account of why you want to conduct research, your academic interests and how they relate to your previous studies and future goals. Maximally two pages long.

Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).

About the employment

The position offered is for, at the most, two years.

A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.

Other information

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It may be the case that a position at KTH is classified as a security-sensitive role in accordance with the Protective Security Act (2018:585). If this applies to the specific position, a security clearance will be conducted for the applicant in accordance with the same law with the applicant's consent. In such cases, a prerequisite for employment is that the applicant is approved following the security clearance.

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Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.